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Known popularly as Nexus, 2C-B is a hallucinogen that was legal in the United States until 1995, when it was classified as a Schedule I drug under the U.S. Controlled Substances Act (CSA). Other Schedule I drugs include opium, heroin, and cocaine. It is a synthetic substance, meaning it is manufactured from chemicals and does not occur naturally. Since 2000, large quantities of the drug have been seized by local police and federal agents in Las Vegas, Chicago, Kansas City, South Dakota, Virginia, and Maine, indicating a nationwide distribution network.
The effects of 2C-B are unpredictable and can be radically violent. It is a hallucinogen that produces euphoria and heightened sensual awareness, including vision, hearing, smell, and touch. Low doses of 4–6 mg make the user become passive and relaxed. High doses of 20–30 mg can cause extreme hallucinations and morbid delusions. The effects usually last from four to eight hours, although they can last for up to 12 hours.
The drug can produce profound distortions in the way a person perceives reality. People under the influence of 2C-B see images, hear sounds, and feel sensations that are not real. It can also produce sudden and intense emotional swings. The drug works by disrupting the normal functions of the serotonin system. Serotonin is a substance widely distributed in nerve cells and acts as a neurotransmitter in the brain.
The chemical properties of 2C-B most closely resemble those of mescaline, and 2C-B is 10 times more powerful than another popular club drug, MDMA (ecstasy). It is considered both a hallucinogen and an entactogen, a term that means “touching within.” The visual effects, including hallucinations, can be more intense than those produced by LSD or “magic mushrooms” (psilocybin), both powerful and potentially deadly drugs in their own right.